The Biomolecular and Proteomics Mass Spectrometry Facility

Proteomics Catalyst Grant Application 

Notice: The CTRI is soliciting applications from CTRI members for Proteomics Catalyst Grants that will exemplify the CTRI mission of developing clinical and translational research, to promote and support the "bench to bedside to community practice and back" goal of the National Institutes of Health. See details below.

About The Biomolecular and Proteomics Mass Spectrometry Facility

The Biomolecular and Proteomics Mass Spectrometry Facility (BMPSF), located on the UCSD campus, is actively engaged in developing proteomic technologies and also provides access to more routine instrumentation for protein and peptide mass spec analyses. The Facility provides expertise in protein sequencing, posttranslational modification (PTM) characterization, and relative and absolute protein quantifications. The core can identify proteins, protein antigen targets in pathogens and transplant tissue, and the constituents of protein complexes. The core has years of experience in PTM characterizations such as protein Ser/Thr and Tyr phosphorylation site determination, protein ubiquitination, methylaion, and acetylation, etc. Protein quantification is the method of choice for disease biomarker discovery in serum and tissue samples. The core has expertise in both label-free and labeled protein quantification and can help you customize these approaches to your specific experimental designs.

Please visit the lab's webpage at massspec.ucsd.edu/bioms for more information about current projects and opportunities for collaboration.

Proteomics Catalyst Grant

Not Currently Active

Description

Funds are being made available for small catalyst grants to initiate projects in clinical proteomics in collaboration with the BMPSF. The goal of the catalyst grants is to facilitate preliminary data collection in preparation for NIH grant applications. The experimental plan and project goals should be discussed with Majid Ghassemian (mghassemian@ucsd.edu) prior to completing the application to facilitate planning of a feasible project. The facility is capable of multidimensional chromatographic separations and quantitative proteomics, and we encourage submissions that will take advantage of these capabilities.

Proposals with the greatest potential to lead to additional external support and/or to be developed into sustainable collaborative projects will be given priority. Each Catalyst Grant is in the form of $3,000 to $5,000 of proteomics services provided through the CTRI-affiliated BMPSF.

Eligibility and Project Requirements

  1. Priority will be given to junior full-time faculty proposing collaborative projects
  2. Principal investigators for these awards must be members of the CTRI. To join, please click here
  3. Principal investigators must be full-time faculty members at UCSD or one of the UCSD partner institutions including SDSU, Salk, Burhnam, J. Craig Venter, LIAI, Rady Children's Hospital, and Palomar Pomerado Health 
  4. Postdoctoral Fellows and Project Scientists are not eligible
  5. Previous awardees are not eligible to reapply for one year
  6. If more than one proposal is submitted by a Principal Investigator and both are scored in the fundable range, only one proposal will be funded (i.e., only the highest scored proposal will be funded)

Full Professors are NOT eligible to be principle investigators unless they are entering a new line of research. Proposals can not overlap with or be a logical extension of ongoing research. In general, proposals from full professors who have greater than $350,000/year in current funding will receive lower priority. 

All investigators selected to receive funding will be asked to submit a progress report at the conclusion of the award.

Evaluation Criteria

Applications should be well-written, precise, and succinct. Applications will be subject to both scientific and programmatic review and will receive scientific review by the CTRI Review Committee. The following criteria will be used in evaluating these proposals:

  1. Significance of the research and its translational relevance
  2. Scientific quality
  3. Feasibility
  4. Probability that the work will yield important new information, technology or service
  5. Qualifications of the principal investigator and collaborators

Presentations and Publications

All publications, grants, and presentations resulting from research funded by the CTRI or using CTRI resources must cite the CTRI as a contributing source of support and indicate the NIH CTSA grant title and number: University of California, San Diego, NIH CTSA grant # 8UL1 TR000100.

Investigators are responsible for submitting any peer-reviewed journal articles resulting from research funded by this award to PubMed Central, the NIH digital archive of biomedical and life sciences journal literature. See http://publicaccess.nih.gov/

Budget Guidelines

The only allowable expense on this award is proteomics services provided by the BMPSF.

Funding Cycle

The number of grants to be awarded depends on quality of the proposals and current CTRI funding levels. Proteomics services must be provided by Oct 1, 2012. Please note: All funds not spent by the end date of Award (Oct 1, 2012) will be returned to the CTRI. No extensions will be granted. Investigators must therefore have IRB approval in place prior to the beginning of the funding cycle so that spending of pilot award funds can begin as soon as possible.

Direct questions about the application process to: ctri-lab@ucsd.edu