Affiliated Biorepositories

In addition to its own biorepositories, the TRT Division has created affiliations with other UCSD biorepositories in order to provide expanded access to samples for CTRI PIs. For each of these affiliated biorepositories there is respective contact information. For further information regarding working with these biorepositories, please call (858) 657-5127) or email (ctrilab@ucsd.edu) the TRT Division.

Name/ Description contact

HIV/AIDS Biorepository

The HIV Research Coordinated Laboratory Services is led by Dr. Davey Smith at UCSD. The facilities are coordinated with the Translational Virology Core of the Center for AIDS Research. The repository collects over 350 blood plasmas, 100 peripheral blood mononuclear cell samples, 40 genital secretions, and 15 cerebrospinal fluid clinical samples each month. The Biorepository has cryopreserved and inventoried more than 100,000 aliquots of blood plasma, 65,000 viably stored aliquots of peripheral blood mononuclear cells, and 5,000 aliquots of cerebrospinal fluid.

Lab Director: Dr. Davey Smith
d13smith@ucsd.edu

Lab Contact: Demetrius dela Cruz
858-642-1620
ddelacruz@ucsd.edu

http://viralpath.ucsd.edu/

Moores Cancer Center Biorepository

The Biorepository contains plasma, serum, RNA stabilized buffy coat, urine, and viable tumor samples from over 2,000 patients; substantial associated clinical information is often available. These can be provided to investigators with Cancer Sample Banking Committee approval (IRB approval is also required for projects requesting ongoing sample collection or clinical annotation.) Urine and blood-derived specimens are available from a wide variety of cancer cases and cancer-free controls.

Tumor sample availability is more limited and predominately murine xenografts generated in the NSG model. Subjects are consented for research germ line genotyping with upload of anonymized data to public databases. Access to the clinical annotation is determined based on need as justified in each investigator's request or protocol.

Lab Director: Scott R. Vandenberg, M.D., Ph.D.
vandenbergoffice@ucsd.edu

Lab Contact: Sharmeela Kaushal, Ph.D.

(858) 822-7661
ccbr@ad.ucsd.edu

Breast Cancer Tissue Repository

The Women's Healthy Eating and Living study, led by Dr. John Pierce of UCSD, involved 3088 women diagnosed with breast cancer between 1991 and 2000. This large, randomized trial tested whether a major increase in consumption of phytoestrogen- and micronutrient-rich vegetables reduced cancer progression and increased survival. Currently this repository has over 70,600 plasma, 102,700 serum, 24,500 red blood cell 24,600 white blood cell aliquots, 27,500 DNA samples, and 8000 unstained tissue samples.

Lab Director: Dr. John Pierce
jppierce@ucsd.edu

Lab Contact: Susan Wancewicz
swancewicz@ucsd.edu
(858) 822-6835

Pediatric Tissue Repository

Rady Children's Hospital has collected tissue from numerous surgical procedures for approximately the last twelve years. The majority of frozen tissue samples are liver, muscle, and renal biopsies. Paraffin embedded and frozen tissue is also available for several types of pediatric neoplasms. Dr. Robert Newbury, Director of Pathology at Rady Children’s Hospital will make this resource available to CTRI members.

Lab Director: Dr. Robert Newbury
rnewbury@rchsd.org
858-966-5944

CNS Neurodegeneration Repository

Three Neuropathology cores at UCSD, under the leadership of Dr. Eliezer Masliah, provide frozen and fixed tissues as well as fluids from patients with Alzheimer¹s Disease, HIV dementia, and movement disorders. Furthermore, the cores support and train users in methods such as stereology, image analysis, confocal microcopy, electron microscopy, synaptic analysis, laser capture, and immunocytochemistry.

Lab Director: Eliezer Masliah, MD
emasliah@ucsd.edu

http://neurosci.ucsd.edu/

1. Alzheimer's Disease Research Center tissue bank collects approximately 50 samples per year. It has over 1200 human brains from deceased individuals who were diagnosed with dementias including Alzheimer's disease, frontotemporal dementia, Creutzfeldt-Jakob disease, Huntington's disease, vascular dementia, and hippocampal sclerosis. Plasma and cerebrospinal fluid are collected in some cases, and in all cases extensive clinical and imaging data are available.

Lab Contact: Sarah Michael
semichael@ucsd.edu

2. California NeuroAIDS Network collects brains, spleen, liver, lymph nodes, and other peripheral tissues from full autopsies of HIV control and dementia cases at an approximate rate of 25 cases per year. The collection now includes over 300 cases with associated clinical and imaging information 3. The Movement Disorders Core collects approximately 10 brains per year from deceased individuals who were diagnosed with Multiple Systems Atrophy, Parkinson's Disease, progressive supranuclear palsy, and other diseases, for a current total of more than 100 brains.

Lab Contact: Wilmar Dumaop
adoboandryce@gmail.com

http://cntn.hivresearch.ucsd.edu/

3. The Movement Disorders Core collects approximately 10 brains per year from deceased individuals who were diagnosed with Multiple Systems Atrophy, Parkinson's Disease, progressive supranuclear palsy, and other diseases, for a current total of more than 100 brains.

Lab Contact: Sarah Michael
semichael@ucsd.edu

Rheumatic Disease Biorepository

Focused on supporting academic and industry research on arthritis and other rheumatic diseases. Includes synovial tissue and blood from rheumatoid and osteoarthritis, and blood from other rheumatic diseases including SLE. The repository includes an extensive collection of primary fibroblast-like synoviocytes. In addition to banked samples, we have capabilities for targeted collection and specialized specimen processing.

Lab Director: Gary S. Firestein, MD
transmed@ucsd.edu
(858) 822 3824

Lab Contact: Josh Hillman
jhillman@ucsd.edu
(619)-543-2693