Pilot Project Award - Currently Closed - check back in fall 2013 for new request for applications
Issue Date: October 2012
The Clinical and Translational Research Institute (CTRI) is soliciting applications from all members, and particularly junior faculty, for Pilot Projects that will help fulfill the CTRI mission of developing clinical and translational research. Our Pilot Project program aligns with the goal of the National Institutes of Health to promote progress from the “bench to bedside to community and practice and back”.
The purpose of this RFA is to support pilot projects that utilize CTRI infrastructure, so that such research can produce preliminary data for competitive proposals to the NIH and other federal funding sources. Proposals with the greatest potential to lead to external support and to be developed into sustainable collaborative projects will be given priority. Projects that utilize the CTRI Center for Clinical Research (http://ctri.ucsd.edu/clinical/Pages/center-clinical-research.aspx) are especially encouraged.
Available Funding Categories:
Clinical Research (up to $25,000)
Translational Research (up to $25,000)
Innovative Technology Research (up to $50,000)
Personalized Medicine Research (up to $50,000)
Clinical Research, according to the NIH definition, is research conducted with human subjects or on material collected from humans, in order to broaden knowledge about mechanisms of disease, therapeutic interventions, or clinical trials, or to develop new technology. Clinical research also includes epidemiological studies, behavioral studies, community interventions, and research on outcomes and health services.
Translational Research is defined to include four emphases:
1) T1 translational research includes the process of applying basic research discoveries to develop trials and other studies in humans (i.e., case series, phase I and II clinical trials).
2) T2 translational research is directed at better patient outcomes and the development of evidence‐based guidelines.
3) T3 translational research implements evidence‐based guidelines into health practice through community practice (delivery, dissemination, and diffusion research).
4) T4 translational research evaluates the health outcomes of applications of translational research in the community.
Innovative Technology Research is defined as projects that develop new technology to assess disease susceptibility, pathogenesis, or severity, and which could be applicable to clinical research. Funding is not intended to support adaptation or modification of existing technology, such as flow cytometry, qPCR, ELISAs, etc. A particular focus on biomarker or imaging modalities is anticipated, such as novel proteomics techniques or developing novel imaging agents. Proposal must include a clinical researcher to serve as co-investigator to assure disease relevance.
Personalized Medicine Research uses genomic information – in addition to family history, lifestyle, and environmental factors – to customize health management. Using these data, in addition to clinical information, more accurate predictions can be made about a person’s susceptibility of developing disease, the course of disease, and response to treatment.
The number of grants to be awarded depends on the quality of the proposals and current CTRI funding levels. Funds must be spent between April 1, 2013 and March 31, 2014. All funds not spent by the end date of the Pilot Project award (March 31,2014) will be returned to the CTRI. No extensions can be granted. Investigators must therefore have IRB approval in place before the beginning of the funding cycle so that spending of pilot award funds can begin as soon as possible.
PLEASE NOTE: As part of its Pilot Projects funding mechanism, the CTRI has developed a funding collaboration with several UCSD organizations such as the UCSD Center for Functional MRI (CFMRI). For CTRI Pilot Project proposals that include human neuroimaging, the CFMRI will support one scan hour (in the form of a pilot hour) for every two scan hours supported by the Pilot Project grant. Other details regarding the assignment and usage of these pilot hours will follow the policies of the CFMRI. This generous collaborative arrangement leverages additional research support for clinical, translational, and innovative technology pilot projects for CTRI investigators using neuroimaging methodologies.
Other areas of research that may be eligible for Pilot Project partnering funds include stem cells, diabetes, and aging. In most instances, these partnerships will enable the funding of additional grants (rather than more funding for a particular grant). The review committee will determine suitability for partnering.
We also encourage collaboration with other CTSA-funded institutions. If you are considering such a collaboration, please contact Dr. Deborah Spector (email@example.com) for further information.
Applications will be received in two stages:
1) The first stage requires a 500-word abstract which will be scored, but no comments will be provided.
2) The second stage is by invitation only based on scores received on the 500-word abstract. A 5-page application is required, which will be scored according to the NIH 9-point scoring guidelines. Comments will be provided to the applicants. Investigators must have IRB approval in place before the beginning of the funding cycle so that spending of pilot award funds can begin as soon as possible. Please submit your IRB application at the same time as submission of your second-stage application. We will require evidence that your application is slated for IRB review prior to CTRI scientific review; if this is not available, your application will be withdrawn for consideration during that cycle.
Application Deadline, Notices of Awards, and Funding Cycle
Application Deadline: November 12, 2012, 5:00 pm
Invitation for Stage II: December 14, 2012
Application Deadline: January 25, 2013, 5:00 pm
Notice of Awards: March 14, 2013
Funding Cycle: April 1, 2013‐ March 31, 2014
Eligibility and Project Requirements
· Priority will be given to junior full-time faculty proposing collaborative projects
· Principal Investigators for these pilot awards must be members of the CTRI. Applicants may join the CTRI shortly before submission and still be eligible. To join, please click on this link: http://ctri.ucsd.edu/about/membership/Pages/membership-application.aspx
· Principal Investigators must be full-time faculty members at UCSD or one of the UCSD partner institutions including SDSU, Salk, Sanford Burnham, J. Craig Venter, LIAI, Rady Children’s Hospital, and Palomar Pomerado. Postdoctoral Fellows and Project Scientists are not eligible.
· Previous awardees are not eligible to reapply for one year.
· Only one pilot proposal may be submitted by a Principal Investigator per funding category.
· Full professors are NOT eligible to be Principal Investigators unless they are entering a new line of research. Proposals cannot overlap with or be a logical extension of ongoing research. In general, proposals from full professors who have greater than $350,000/year in current funding will receive lower priority.
All investigators selected to receive funding will be required to submit a six-month progress report and a one-year Final Progress Report at the end of the funded project. An additional report one year later will also be required. This report will consist of a detailed description of progress to date and a listing of all submitted publications and grant applications (pending or funded), meeting abstracts, and seminars relating to the pilot project.
Applications should be well-written, precise, and succinct. Applications will be subject to both scientific (by the CTRI Review Committee) and programmatic review. The following criteria will be used in evaluating these proposals:
1) Significance of the research and its translational relevance
2) Scientific quality
4) Probability that the work will yield important new information, technology, or service
5) Qualifications of the Principal Investigator and collaborators
Presentations and Publications
Awardees are expected to publish their findings in scholarly peer‐reviewed journals and present their research at professional meetings.
All publications, grants, and presentations resulting from research funded by the CTRI or using CTRI resources must cite the CTRI as a contributing source of support and indicate the NIH CTSA grant title and number: University of California, San Diego, NIH CTSA grant # 5UL1TR000100.
If a project is required to be registered at Clinicaltrials.gov, the Principal Investigator is responsible for doing so before beginning the research. CTRI staff can help investigators with this process.
Investigators are responsible for submitting any peer‐reviewed journal articles resulting from research funded by this award to PubMed Central, the NIH digital archive of biomedical and life sciences journal literature. See http://publicaccess.nih.gov/.
All guidelines pertaining to allowable expenses on federal grants will be applicable for these awards. In addition, no funding will be provided for travel, clerical help, office supplies, books and subscriptions, graduate student support and tuition remission, or publication expenses. It is not expected that findings from these awards will be ready for presentation during the funding period. If equipment is budgeted, it will need a thorough justification. As a reminder, these are pilot projects to obtain preliminary data.
How to Apply for Stage 1
a) 500-word abstract
b) NIH biographical sketches, including other support with yearly direct costs, for the significant participants
c) The abstract page from all ongoing funded and pending research proposals
How to Apply for Stage 2
Stage 2 applications are by invitation only based on scores received for Stage 1 applications.
The 5-page application should follow NIH proposal criteria:
a) Specific Aims
b) Background and Significance
c) Preliminary Studies (if applicable)
d) Research Design and Methods
e) Literature Cited (not included in the 5-page limit)
f) A detailed budget using PHS 398 form with budget justification must be included (NOTE: budget is not included in the 5-page limit)
g) IRB applications must be submitted at the same time as the Stage 2 submission, and should provide evidence of IRB (HRPP) pending review (e.g., HRPP # for the project).
h) Applications should adhere to the following formatting specifications:
- 11‐point Arial font
- 0.5 inch margins on all sides
- 8 ½” x 11” (i.e., standard size) paper
- Number all pages
- No appendices are allowed
How to Submit your Applications:
The application is available online http://ucsd.dullestech.net/ .You must register as an applicant. You will be sent an email notifying you of your username and password after you register.
Please contact Murray Stein MD, MPH at firstname.lastname@example.org or 858-534-6400; or Kathleen Kennedy at email@example.com or (858) 657-5143 with any questions about this RFA or the application process.